How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?

Figure 2

IL-22 and IL-22BP interaction in regulation of liver fibrosis. IL-22 is produced by a number of cells (activated T cells and NK cells) and helps prevent liver fibrosis by increasing the survival rate of hepatocytes and promoting HSCs senescence and by binding to IL-22R complex. IL-22BP has more affinity for IL-22 than IL-22R1 and hence it prevents IL-22 binding to IL-22R complex and checks antifibrotic activity when binding to IL-22.