Review Article

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

Figure 2

Neutrophil MPO suppresses DC function and adaptive immunity. Odobasic et al. [21] showed that rapidly infiltrating neutrophils release MPO in draining lymph nodes (LN) after antigen/adjuvant injection. The deposited MPO suppresses various aspects of DC function including costimulatory molecule (e.g., CD86) expression and cytokine (IL-12, IL-23) production and migration, resulting in decreased generation of CD4 T cell responses including T cell activation (CD44 expression), proliferation, and differentiation into Th1 (IFNγ-producing) and Th17 (IL-17A-releasing) effectors.