Research Article
F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo
Figure 3
Increase in host F4/80+ splenic macrophages in ESHP recipients. (a) Absolute numbers of host-derived Gr-1+ cells, (b) absolute numbers of host-derived CD11b+ cells, (c) absolute numbers of host F4/80+ macrophages in ESHP recipients (CD41 filled triangles, , and CD45 filled squares, ), untransplanted NSG mice (), and whole BMT recipients (). Bars represent mean and SEM. (d) Immunohistochemistry of F4/80+ macrophages (red-AEC) in spleen sections at days 17–20 after transplant, taken at 40x magnification.
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