PD-1/PD-L1 Interaction Maintains Allogeneic Immune Tolerance Induced by Administration of Ultraviolet B-Irradiated Immature Dendritic Cells

Figure 3

Tolerance induced by injection of UVB-iDCs prolongs the skin allograft survival. Six weeks after the last treatment for tolerance induction as described elsewhere, the tolerant and naïve C3H mice were transplanted with Balb/c skin grafts as described in Section 2. The graft survival was monitored daily for 30 days. (a) The condition of a representative transplanted flap from each group is exhibited. (b) The graft survival of each group was shown. Six mice were included in each group. The survival data were analyzed by Log Rank test. (tolerant group versus naïve group).

(a)

(b)