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Journal of Immunology Research
Volume 2016, Article ID 2695396, 11 pages
Review Article

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

1Department of Infectious Diseases, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
2Department of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3010, Australia

Received 18 April 2016; Revised 28 June 2016; Accepted 10 July 2016

Academic Editor: Nathalie Rouas-Freiss

Copyright © 2016 Simone A. Joosten et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8+ T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.