Journal of Immunology Research / 2016 / Article / Tab 2

Review Article

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Table 2

T-cell properties of MHC class Ib restricted T-cells; phenotype, cytokine production, transcription factors, cytolytic molecules.

AntigenT-cell phenotypeCytokinesTranscr. factorsFunctionReference
CD3 CD8 TCRαβ CD25 LAG3 CD39 CTLA4 CD45RA CD45RO CCR7 CD27 CD28 CD56 CD57 CD62L CD94 Perforin Granzyme A Granzyme B Granulysin CD107a TRAIL TCR Vβ16 TCR Vβ22 IFNγ TNFα IL-2 IL-4 IL-5 IL-10 IL-13 IL-17 TGF-β MIP-1β T-bet GATA3 RORC FOXP3 EOMES Spec. target lysis Path. killing T-cell suppr. TM binding

SelfVMAPRTLVL+++[42]

SelfVTAPRTVLL+++[34]⁢
VMAPRTLVL+++
VMAPRTLIL+++
VMAPRALLL+++
VMAPRTLFL+++

SelfVMAPRTLIL, VMAPRTLLL++++++[35]

SelfQMRPVSRVL+++++[45]

SelfSLELGDSAL++[33]⁢
LLLGPGSGL++

EBVSQAPLPCVL+++[34]

EBVSQAPLPCVL++++++[35]

EBVSQAPLPCVL++[36]

CMVVMAPRTLIL++++[37, 39]

CMVVMAPRTLIL+++++++++[38]

CMVVMAPRTLIL, VMAPRTLVL+++[12]

CMVVMAPRTLLL+++lohi#+++++++?+[41]

CMVVMAPRTLIL+++[40]

HCVYLLPRRGPRL++[44]

SalmonellaGMQFDRGYL+++++[43]⁢
AMLQDIATL+++++
KMLRGVNVL+++++
VEGEALATL+++++
AAVEELKAL+++++
AVAKAGKPL+++++
KLQERVAKL+++++

Salmonella?++#+++#++[46, 49]

Mtb?++[31, 32]

Mtb69 peptides+++++#++#++[30]

MtbRMPPLGHEL++++++++#+++#+##+#++#++++[47]⁢⁢
VLRPGGHFL++++++++#+++#+##+#++#++++

MtbVMTTVLATL+++##+#+++[48]⁢
RLPAKAPLL+++##+#+++
VMATRRNVL+++##+#+++
RMPPLGHEL+++##+#+++
VLRPGGHFL+++##+#+++


“+” = positive in most samples; “−” = hardly seen; #: observed in about half of the samples; : membrane bound TGF-β, not secreted.

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