Journal of Immunology Research

Review Article

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

Table 2

T-cell properties of MHC class Ib restricted T-cells; phenotype, cytokine production, transcription factors, cytolytic molecules.
 AntigenT-cell phenotypeCytokinesTranscr. factorsFunctionReference
CD3 CD8 TCRαβ CD25 LAG3 CD39 CTLA4 CD45RA CD45RO CCR7 CD27 CD28 CD56 CD57 CD62L CD94 Perforin Granzyme A Granzyme B Granulysin CD107a TRAIL TCR Vβ16 TCR Vβ22 IFNγ TNFα IL-2 IL-4 IL-5 IL-10 IL-13 IL-17 TGF-β MIP-1β T-bet GATA3 RORC FOXP3 EOMES Spec. target lysis Path. killing T-cell suppr. TM binding
SelfVMAPRTLVL ++                                    +   [42]
SelfVTAPRTVLL +                    +                +   [34]⁢
VMAPRTLVL +                    +                +   
VMAPRTLIL +                    +                +   
VMAPRALLL +                    +                +   
VMAPRTLFL +                    +                +   
SelfVMAPRTLIL, VMAPRTLLL ++         +  +                       +  +[35]
SelfQMRPVSRVL +              +++                    +   [45]
SelfSLELGDSAL +                                     +   [33]⁢
LLLGPGSGL +                                     +   
EBVSQAPLPCVL +                    +                +   [34]
EBVSQAPLPCVL ++         +  +                       +  +[35]
EBVSQAPLPCVL +                                        +[36]
CMVVMAPRTLIL ++        −                           +  +[37, 39]
CMVVMAPRTLIL +     ++−−−+   +     + + −            +  +[38]
CMVVMAPRTLIL, VMAPRTLVL +                    +                   +[12]
CMVVMAPRTLLL+++    lohi−−#+−− +++    +++             ?  +[41]
CMVVMAPRTLIL       +  −     +                         +[40]
HCVYLLPRRGPRL +                      +                  [44]
SalmonellaGMQFDRGYL++          −     +     +              +   [43]⁢
AMLQDIATL++          −     +     +              +   
KMLRGVNVL++          −     +     +              +   
VEGEALATL++          −     +     +              +   
AAVEELKAL++          −     +     +              +   
AVAKAGKPL++          −     +     +              +   
KLQERVAKL++          −     +     +              +   
Salmonella?++     #      −     +   ++#    + +         [46, 49]
Mtb? +                      +                  [31, 32]
Mtb69 peptides+++++ −         # ++    #           − + + [30]
MtbRMPPLGHEL+++++++− +      #+++    #+##+#+   −+−−#++++[47]⁢⁢
VLRPGGHFL+++++++− +      #+++    #+##+#+   −+−−#++++
MtbVMTTVLATL+++             − #− #  −+−#−−+−       +− +[48]⁢
RLPAKAPLL+++             − #− #  −+−#−−+−       +− +
VMATRRNVL+++             − #− #  −+−#−−+−       +− +
RMPPLGHEL+++             − #− #  −+−#−−+−       +− +
VLRPGGHFL+++             − #− #  −+−#−−+−       +− +
“+” = positive in most samples; “−” = hardly seen; #: observed in about half of the samples; : membrane bound TGF-β, not secreted.