Journal of Immunology Research

Review Article

Immunomodulatory Effects Mediated by Dopamine

Table 1

Dopaminergic proteins expressed in immune cells.


	D1R	D2R	D3R	D4R	D5R	VAT1/2	DAT	TH	DDC	DβH	PAH

Cellular types	T cell [76], [77]B cells [77], [78]Dendritic cells [75] HMDM [79], [80], [81] NK cells [82] CD4⁺ CD25⁻ T lymphocytes [83] Teff [84] CD4⁺ lymphocytes (naive, central memory, effector memory) [85] Treg [83], [84] Tonsil [86] T cell mesenteric lymph nodes [87]	B cells [88], [78]T cell [76], [88], [89], [90] CD4⁺CD25⁻ T lymphocytes [83] Teff [84] CD4⁺ lymphocytes (naive, central memory, effector memory) [85], [88], [91] Treg [83], [84] Dendritic cells [75] HMDM [79], [80] Monocytes [88] Eosinophils [88] Neutrophils [88] NK cell [88], [82] Resting NK cells [92] PBMC [93] T cell CD4⁺ resting [86] T cell CD4⁺ activated [86] Tonsil, thymus [86] T cell mesenteric lymph nodes [87]	B cells [88] , [78]Lymphocytes [94], [95], [96] CD4⁺ CD25⁻ T lymphocytes [83], [88] Teff [84] CD4⁺ lymphocytes (naive, central memory, effector memory) [85] Treg [83], [84] T cells [97], [89] T cell [90] Dendritic cells [75] HMDM [79] Monocytes [88] Eosinophils [88] Neutrophils [88] NK cell [88], [82] Resting NK cells [92] PBMC [93] T cell CD4⁺ resting [86] T cell CD8⁺ resting [86], [98] Tonsil, thymus, lymph nodes [86] T cell mesenteric lymph nodes [87]	B cells [88] Lymphocytes [94], [96], [99]CD4⁺ CD25⁻ T lymphocytes [83] Teff [84], [88] CD4⁺ lymphocytes (naive, central memory, effector memory) [85] Treg [83], [84] Anti-CD3⁺CD28⁺ induced T cells [100] HMDM [79] Monocytes [88] Eosinophils [88] Neutrophils [88] NK cell [88], [82] Resting NK cells [92] PBMC [93] T cell CD8⁺ resting [86], [98] T cell CD8⁺ activated [98] Monocytes CD14⁺ resting [86] B cell CD19⁺ resting [86] Tonsil, thymus [86] T cell mesenteric lymph nodes [87]	B cells [88], [78] Lymphocytes [101], [102]CD4⁺ CD25⁻ T lymphocytes [83], [88] CD4⁺ lymphocytes (naive, central memory, effector memory) [85] T cell [90] Treg [83], [84] Dendritic cells [75] HMDM [79] Monocytes [88] Eosinophils [88] Neutrophils [88] NK cell [88], [82] Resting NK cells [92] PBMC [93] Thymus [86] T cell CD8⁺ resting [98] T cell mesenteric lymph nodes [87]	Immature dendritic cells [75]Lymphocytes [103] CD4⁺ CD25⁻ T lymphocytes [83] HMDM [79] Treg [83]	Lymphocytes [103], [104], [105], [91]HMDM [79] B cells [78]	Lymphocytes [103], [106]PBMC, T and B Lymphocytes [77] Treg [83] HMDM [79] Th1 and Th2 Lymphocytes [107] Dendritic cells [75] Lymphocytes ConA activated [108] Mesenteric lymph nodes, thymus, lymphocytes [108]	HMDM (human monocyte-derived macrophages) [79]Leukocytes [109] U937 cells, model of human macrophages [110]	T/B cells [111]	Leucocytes [112], [113], [114]

Human, murine, expression, protein, and very low signal.