Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45

Figure 4

Characterization of the cellular response to ovalbumin vaccination. Each dot or triangle represents an individual mouse. Each PBS vaccination consisted of four mice and each ovalbumin vaccination group of five mice. Comparisons between groups were performed by Student’s -test. (a) Percentage of IFN-g secreting CD3 and CD8 double positive cells. (b) Percentage of IFN-g secreting CD3 and CD4 double positive cells. (c) Percentage of IL-17 secreting CD3 and CD4 double positive cells. (d) Percentage of Foxp3 positive CD3 and CD4 double positive cells. NS = nonsignificant; = significant difference ; OMVs = bacterial outer membrane vesicles; CT = cholera toxin.

(a)

(b)

(c)

(d)