Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects

Figure 1

Current status of clinical trials of chimeric antigen receptor-modified T (CART) cells in malignancies. These data were searched on 15 June, 2015, from the website ClinicalTrials.gov (http://www.clinicaltrials.gov). The key phrases “chimeric antigen receptor-modified T cells”, “chimeric antigen receptor”, “CART”, and “CAR” were used. (a) Comparison of the number of registered CART-cell trials for solid tumors and hematological malignancies on the ClinicalTrials.gov website. (b) The registered solid tumor targets for CART cells on the ClinicalTrials.gov website. EGFR: epidermal growth factor receptor; FAP: fibroblast activation protein; PSMA: prostate-specific membrane antigen; VEGFR2: vascular endothelial growth factor receptor 2. (c) Proportion of annual registered numbers of CART cells in solid tumors on the ClinicalTrials.gov website.

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