Prophylactic Chronic Zinc Administration Increases Neuroinflammation in a Hypoxia-Ischemia Model

Figure 4

Effect of prophylactic chronic administration of zinc and CCAO on protein levels of chemokines and their receptors in the temporoparietal cortex-hippocampus using ELISA. CZn15 d, rats with chronic administration of zinc; Zn15 d+CCAO 8 h, rats with chronic administration of zinc before CCAO and evaluations at 8 h after reperfusion; Zn15 d+CCAO 7 d, rats with chronic administration of zinc before CCAO and evaluations at 7 days after reperfusion. Experimental values were normalized with respect to those of untreated controls. Each value represents the mean ± SEM of 5 independent experiments made in triplicate. different from untreated rats (Student’s -test). The significance was established at .

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