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Observation | Correlation with outcome of pregnancy | Author |
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HLA-G+ EVT but not HLA-G− VT have immune activating potential and induce Tregs | — | Tilburgs et al. [13] |
dNK acquired HLA-G through interaction with EVT and can be reactivated by cytokine stimulation | — | Tilburgs et al. [46] |
High HLA-G levels in placental bed correlated with high expression of KIR2DL4 and LILRB1 on dNK cells | — | Djurisic et al. [47] |
Enhancer L on HLA-G gene is controlled by CEBP and GATA that are also essential for placentation | — | Ferreira et al. [48] |
sHLA-G is higher in maternal blood at GW20 than at term and higher in maternal blood than in umbilical blood | — | Klitkou et al. [49] |
Higher 14 bp alleles in fetus are related to higher sHLA-G in maternal blood at term | — | Dahl et al. [50] |
sHLA-G in seminal plasma is related to 14 bp ins/del genotype and can predict the success of ART | Positive correlation with the success of ART | Dahl et al. [51] |
Higher frequency of 14 bp ins alleles in HLA-G gene is related to the outcome of pregnancy | Positive correlation with RIF | Lashley et al. [52] |
Higher sHLA-G and frequency of KIR2DL4+ NK cells in uterine flushing samples from secondary infertile women than in primary infertile woman | Negative correlation with infertility | Rizzo et al. [53] |
SNP in 3′ UTR of HLA-G gene is related to outcome of pregnancy | Positive correlation with high risk of preeclampsia | Quach et al. [54] |
SNP in 5′ URR of HLA-G gene is related to outcome of pregnancy | Positive correlation with RSA | Agrawal et al. [55] |
Lower sHLA-G and PAPP-A in women with GDM at third trimester | — | Beneventi et al. [56] |
Higher sHLA-G in women with preexisting rheumatic disease at third trimester | Positive correlation with the success of pregnancy | Beneventi et al. [57] |
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