|
| Type of disease | Observation | Correlation with clinical outcome | Author |
|
| CD | Several polymorphisms and one haplotype of HLA-G gene are more frequent in patients than in controls | Positive correlation with susceptibility | Catamo et al. [58] |
| RA | Several polymorphisms and two haplotypes of HLA-G gene are more frequent in patients than in controls | Positive correlation with susceptibility | Catamo et al. [59] |
| RA | Two polymorphisms of HLA-G gene are more frequent in RF+ than in RF− patients | Positive correlation with disease severity | Mariaselvam et al. [60] |
| RA | Homozygosis of 3142G allele is related to lower sHLA-G levels | Positive correlation with high risk of disease | Veit et al. [61] |
| RA | Higher sHLA-G levels in patients with chronic disease and higher LILRB1 binding in RF− patients | Negative correlation with disease severity | Veit et al. [62] |
| SLE | HLA-G 14 bp ins/del polymorphisms are associated with susceptibility | Positive correlation with susceptibility | Zhang et al. [63] |
| SSc | Lower levels of sHLA-G in patients than in controls | Negative correlation with disease severity | Favoino et al. [64] |
| CD | Higher levels of sHLA-G in patients than in controls | Positive correlation with susceptibility | Zidi et al. [65] |
| MS | Higher sHLA-G dimers in MS than in controls and in MRI− than in MRI+ | Positive correlation with termination of inflammatory response | Fainardi et al. [66] |
| MS | 14 bp ins in HLA-G gene is related to lower sHLA-G levels | Positive correlation with high risk of disease | Mohammadi et al. [67] |
| T1D | Lower sHLA-G levels in pancreas are detrimental | Negative correlation with disease severity | de Albuquerque et al. [68] |
| Psoriasis | 14 bp del/del genotype of HLA-G gene is more frequent in patients responding to therapy | Positive correlation with response to treatment | Borghi et al. [69] |
| Asthma | SNPs in 3′ UTR of HLA-G gene modulate the binding of mIRNAs | Positive correlation with high risk of disease | Naidoo et al. [70] |
|
