| | Type of TLR | Immune cells | Tumor cells |
| | TLR1 | cDCs, eosinophils, monocytes, neutrophils, NK cells, pDCs, B cells | Myeloma cells | | TLR2 | cDCs, monocytes, neutrophils, NK cells, B cells, T cells | Breast cancer, gastric carcinoma, HCC, intestinal carcinoma, laryngeal carcinoma, myelogenous leukemia, oral squamous cell carcinoma | | TLR3 | cDCs, NK cells | Breast cancer, cervical cancer, CRC, esophageal squamous cell carcinoma, gastric carcinoma, HNSCC, HCC, laryngeal carcinoma, lung carcinoma, melanoma, myelogenous leukemia, neuroblastoma cells, ovarian cancer, pharyngeal carcinoma (cell lines), prostate cancer | | TLR4 | cDCs, eosinophils, monocytes, neutrophils | Adrenocortical carcinoma, breast cancer, cervical cancer, CRC, epithelial ovarian cancer, esophageal squamous cell carcinoma, gastric carcinoma, HNSCC, intestinal carcinoma, laryngeal carcinoma, HCC, lung carcinoma, melanoma cell lines, myelogenous leukemia, neuroblastoma, ovarian cancer, pancreatic cancer, prostate cancer, skin cancer | | TLR5 | cDCs, monocytes, neutrophils, NK cells, T cells | Breast cancer cells, cervical squamous cell carcinoma, CRC, gastric carcinoma, intestinal carcinoma, ovarian cancer | | TLR6 | cDCs, monocytes, neutrophils, NK cells, B cells | | | TLR7 | Eosinophils, monocytes, neutrophils, pDCs, B cells | CRC, esophageal squamous cell carcinoma, lung carcinoma, myeloma cells, pancreatic ductal adenocarcinoma | | TLR8 | cDCs, monocytes, neutrophils
T cells, Tregs | CRC, lung carcinoma | | TLR9 | Eosinophils, monocytes, neutrophils, pDCs, B cells | Breast cancer, cervical squamous cell carcinoma, CRC, esophageal squamous cell carcinoma, gastric carcinoma, lung carcinoma, myeloma cells, myelogenous leukemia, ovarian cancer (cell lines), prostate cancer, renal cell carcinoma | | TLR10 | Eosinophils, monocytes, neutrophils, pDCs, B cells, T cells, Tregs | CRC |
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