Sipuleucel-T and Androgen Receptor-Directed Therapy for Castration-Resistant Prostate Cancer: A Meta-Analysis

Table 1

Quality indicators by Newcastle-Ottawa Scale.

Studies	Selection				Comparability		Exposure			Score
	(1)	(2)	(3)	(4)	(5A)	(5B)	(6)	(7)	(8)
Beer and Tombal, 2014	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	8
Fizazi et al., 2012	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9
Higano et al., 2009	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	8
Kantoff et al., 2010	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9
Rathkopf et al., 2014	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	9
Scher et al., 2012	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	8
Small et al., 2006	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	8

(1): case independent validation; (2): representativeness of the cases; (3): community or hospital controls; (4): history of disease; (5A): study controls for the most important factor; (5B): study controls for any additional factor; (6): ascertainment of exposure; (7): was follow-up long enough for outcomes to occur? (8): adequacy of follow-up of cohorts.