Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer

Table 1

Levels of tumour-infiltrating lymphocytes (TILs) in women with LLABCs⁽¹⁾ and subsequent pathological complete response following NAC⁽²⁾.

TILs	Groups	Low infiltration ()	High infiltration ()	Pearson chi-square value; (PCR^(3) versus non-PCR)	value
Intratumoural	Pathological complete response (PCR, )	6	10	11.890	0.001
	Nonpathological complete response (non-PCR, )	16	1
Stromal	Pathological complete response (PCR, )	3	13	16.051	<0.001
	Nonpathological complete response (non-PCR, )	15	2
LPBC^(4)	Pathological complete response (PCR, )	3	13	13.350	<0.001
	Nonpathological complete response (non-PCR, )	14	3

LLABCs: large and locally advanced breast cancers; ⁽²⁾NAC: neoadjuvant chemotherapy; ⁽³⁾PCR (grade 5): no residual invasive disease; ⁽⁴⁾LPBC: lymphocyte-predominant breast cancer; statistically significant.