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Journal of Immunology Research
Volume 2016, Article ID 4951587, 10 pages
http://dx.doi.org/10.1155/2016/4951587
Research Article

Common Variable Immunodeficiency and Circulating TFH

1Instituto de Investigaciones Hematológicas (IIHEMA), Academia Nacional de Medicina, C1425ASU Ciudad Autónoma de Buenos Aires, Argentina
2IMEX-CONICET, Academia Nacional de Medicina, C1425ASU Ciudad Autónoma de Buenos Aires, Argentina
3Unidad de Alergia, Asma e Inmunología Clínica, C1035AAT Ciudad Autónoma de Buenos Aires, Argentina

Received 3 December 2015; Revised 15 February 2016; Accepted 22 February 2016

Academic Editor: Teresa Espanol

Copyright © 2016 Ana Coraglia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.