Research Article

The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis

Figure 4

T cell and macrophage infiltration of the retina from germ-free (GF) mice (a, b), from mice treated with antibiotics (ATB) administered from one week (c, d), or from the day of EAU induction (e, f) and conventional (CV, water) mice 35 days after EAU induction. (a, c, e) CD3+ cells (T-lymphocytes) are shown both distributed as single cells in inner and outer retinal layers (arrows), in the vitreous (arrowheads) and concentrated as clumps in granulomas (stars). (b, d, f) F4/80+ cells (macrophages) are either present as single cells, in inner retinal layers (arrows), or accumulated in the periphery of granulomas (stars). Each point in the graphs shows the sum of all positive cells counted in two sections, one from periphery and one from the centre, from one randomly selected eye. The red lines in the graphs represent mean. (Mann-Whitney test).
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