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Journal of Immunology Research
Volume 2016 (2016), Article ID 5134329, 8 pages
Review Article

Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity

Institut für Physiologie, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany

Received 9 November 2015; Revised 7 January 2016; Accepted 13 January 2016

Academic Editor: Silvia Beatriz Boscardin

Copyright © 2016 Sandra Winning and Joachim Fandrey. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Dendritic cells (DCs) are considered as one of the main regulators of immune responses. They collect antigens, process them, and present typical antigenic structures to lymphocytes, thereby inducing an adaptive immune response. All these processes take place under conditions of oxygen shortage (hypoxia) which is often not considered in experimental settings. This review highlights how deeply hypoxia modulates human as well as mouse immature and mature dendritic cell functions. It tries to link in vitro results to actual in vivo studies and outlines how hypoxia-mediated shaping of dendritic cells affects the activation of (innate) immunity.