Donor Cell Composition and Reactivity Predict Risk of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Figure 2

The non-GVHD group had higher frequencies of CD94⁺, TCRγδ⁺, CD56⁺, and CD95⁺ T-cell subsets than the GVHD group in unmanipulated donor samples. Each dot represents the cell-subset frequency of one donor and horizontal bars indicate the median of each group. Representative FACS plots are shown below each dot-plot of one non-GVHD and one GHVD patient. Statistical analysis was done with the Mann–Whitney test. (a) Percentages of CD94⁺, TCRγδ⁺, and CD95⁺ naïve T-cells were increased within the non-GVHD group. (b) CD94 was expressed to a higher degree on terminally differentiated T-cells within the non-GVHD group. (c) Percentages of CD56⁺ CD4⁺ T-cells were increased within the non-GVHD group.

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