Identification of Novel Vaccine Candidates against Campylobacter through Reverse Vaccinology

Table 1

Potential vaccine candidates selected by the Vaxign program. Localization and length were obtained by the Vaxign program, antigenic score was obtained by the VaxiJen program, and the number of B-cell epitopes was obtained from both BCPreds and AAP methods. The calculated ratio between the number of B-epitopes and protein length is also shown. The two candidates eliminated because of a low antigenic score are shown in italics.

Protein accession	Description	ID	Localization	Length (aa)	Vaxijen score	BCPreds B-epitopes		AAP B-epitopes
						N	Ratio N/length	N	Ratio N/length
YP_001000996.1	Flagellin B	FlaB	Extracellular	576	0.7650	10	0.017	11	0.019
YP_001000997.1	Flagellin A	FlaA	Extracellular	576	0.8185	11	0.019	12	0.021
YP_001001371.1	Flagellar hook protein	FlgE	Extracellular	838	0.7659	16	0.019	18	0.021
YP_001000562.1	Flagellin protein family		Extracellular	750	0.6965	15	0.020	15	0.020
YP_001000248.1	Flagellar capping protein	FliD	Extracellular	642	0.7021	11	0.017	11	0.017
YP_001000204.1	Putative periplasmic protein		OMP	553	0.6702	11	0.021	11	0.021
YP_001000654.1	Putative periplasmic protein		OMP	553	0.6702	11	0.021	11	0.021
YP_999769.1	Flagellar hook protein	FlgE-1	Extracellular	545	0.6567	10	0.018	12	0.022
YP_001001115.1	Flagellar hook-associated protein	FlgK	Extracellular	608	0.5836	11	0.018	10	0.016
YP_001000153.1	TonB-dependent receptor, putative, degenerate		OMP	704	0.5437	12	0.017	9	0.013
YP_001000945.1	N-Acetylmuramoyl-L-alanine amidase		OMP	659	0.6475	9	0.014	11	0.017
YP_001001027.1	Serine protease		OMP	1121	0.5268	9	0.008	11	0.010
YP_001000437.1	Putative OMP		OMP	508	0.6122	9	0.018	6	0.012
YP_999838.1	Hypothetical protein		OMP	400	0.6809	5	0.013	9	0.023
YP_999817.1	Hypothetical protein		OMP	315	0.7827	6	0.019	7	0.022
YP_001000383.1	Flagellar basal body L-ring protein	FlgH	OMP	232	0.6978	6	0.026	4	0.017
YP_001000935.1	Major OMP	PorA	OMP	424	0.6051	5	0.012	5	0.012
YP_001001008.1	Phospholipase A	PldA	OMP	329	0.5819	4	0.012	3	0.009
YP_001001257.1	TonB-dependent heme receptor	ChuA	OMP	702	0.6213	7	0.010	5	0.007
YP_001000615.1	Hypothetical protein		Extracellular	294	0.5498	3	0.010	3	0.010
YP_001000663.1	Surface-exposed lipoprotein	JlpA	OMP	372	0.6642	2	0.005	3	0.008
YP_001000261.1	Hypothetical protein		OMP	309	0.5149	2	0.006	3	0.010
YP_001000503.1	Hypothetical protein		Extracellular	444	0.4603	/	/	/	/
YP_001000297.1	Major antigenic peptide	PEB4	OMP	273	0.4511	/	/	/	/