The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape

Table 2

Abnormality of DNA methylation in RASFs.

Epigenetic alterations	Function	References
Global genomic hypomethylation and decrease of DNMT1 protein expression	Increase of 186 gene expressions	[93]
Normal DNMT1 gene expression	Decrease of DNMT1 gene expression after IL-1 stimulation	[94]
Hypermethylation	Decrease of DR3 involved in resistance to apoptosis	[95]
Hypomethylation	Increase of TBX5 involved in chemokine production	[86]
Hypomethylation	Increase of CXCL12 involved in inflammation	[96]
Genome-wide differential methylation	1859 differentially methylated loci	[97]
Genome-wide differential methylation	2375 differentially methylated loci	[98]