Journal of Immunology Research

Journal of Immunology Research / 2016 / Article
Special Issue

Dendritic Cells in Tolerance and Immunity against Pathogens

View this Special Issue

Editorial | Open Access

Volume 2016 |Article ID 6438036 | https://doi.org/10.1155/2016/6438036

Silvia Beatriz Boscardin, Daniela Santoro Rosa, Alice O. Kamphorst, Christine Trumpfheller, "Dendritic Cells in Tolerance and Immunity against Pathogens", Journal of Immunology Research, vol. 2016, Article ID 6438036, 2 pages, 2016. https://doi.org/10.1155/2016/6438036

Dendritic Cells in Tolerance and Immunity against Pathogens

Received21 Mar 2016
Accepted23 Mar 2016
Published31 Mar 2016

Dendritic cells (DCs) are a highly specialized population of antigen-presenting cells that play a key role in the induction of adaptive immune responses against different pathogens and in the maintenance of peripheral tolerance [1, 2]. Since their discovery by Ralph Steinman in the 70s [36], much has been learned about their ontogeny, migration, and antigen presentation capacities in lymphoid and nonlymphoid organs [7]. Advances in flow cytometry allowed the selection of surface markers that help distinguish different DC subsets [8]. In addition, the identification of many receptors has added information on how these cells sense the environment and respond to different stimuli [9]. The role of DCs in the induction of immune responses and/or in peripheral tolerance has been extensively studied, particularly in mice, using different models that include infectious diseases and cancer, but also autoimmune diseases. In addition, progress has been made in our understanding of human DC subsets.

In this special issue, a number of review articles will illustrate our current understanding of how DCs are affected in different contexts, ranging from inflammatory to more tolerogenic settings. For example, J. M. Motta and V. M. Rumjanek will discuss how different environments affect DC function. They focus especially on how DC function is modulated in the presence of tumors (a tolerogenic setting) or in the presence of organ transplantation (a more proinflammatory setting). The role of DCs following heart transplantation is also revised by M.-T. Dieterlen et al., when they additionally discuss in detail DC function in hypertension, atherosclerosis, and heart failure. On the other hand, S. Winning and J. Fandrey discuss how hypoxia modulates DC function. This is an important topic because antigen presentation normally takes place in organs and tissues that exhibit low oxygen tension, and we are just starting to recognize hypoxia as a key factor on the modulation of immune responses. On a more tolerant setting, we will learn from A. Steimle and J.-S. Frick how intestinal DCs interact constantly with different species of commensal bacteria and how these bacteria can regulate DC phenotype. DC function and tolerance break in systemic lupus erythematosus are addressed by X. Liao et al. Recent evidence suggests that DC activation by self-antigens contributes to tolerance breakdown and to the induction of lupus pathogenesis. The role of DCs in different contexts of infection is also the focus of three reviews in this special issue. N. A. Mabbott and B. M. Bradford address how prions may exploit conventional DCs to infect the host, while D. Feijó et al. and K. N. S. Amorim et al. focus on DC interactions with two different intracellular parasites. Interactions between DCs and parasites from the genus Leishmania are discussed by D. Feijó et al., while K. N. S. Amorim et al. overview the importance of DCs during Plasmodium infection and how they sense different parasite components. Finally, I. G. Zizzari et al. specifically address how a DC receptor recognizes modified glycoproteins expressed by tumors and highlight the importance of antigen structure in the modulation of DC mediated immune responses.

New information is also provided by this special issue. T. Bertran et al. analyze interactions between Gardnerella vaginalis and human monocyte-derived DCs, while D. Clarke et al. study how DCs in contact with group B Streptococcus modulate activation of CD4+ T cells.

In conclusion, this special issue highlights different functions of DCs in complex scenarios such as immunity and tolerance. Understanding how DCs help our immune system to deal with infections and to maintain the steady state is important, and such knowledge may be used in the design of better vaccines and in the treatment of autoimmune diseases.

Silvia Beatriz Boscardin
Daniela Santoro Rosa
Alice O. Kamphorst
Christine Trumpfheller

References

  1. R. M. Steinman and H. Hemmi, “Dendritic cells: translating innate to adaptive immunity,” Current Topics in Microbiology and Immunology, vol. 311, pp. 17–58, 2006. View at: Google Scholar
  2. R. M. Steinman and M. C. Nussenzweig, “Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 1, pp. 351–358, 2002. View at: Publisher Site | Google Scholar
  3. R. M. Steinman, J. C. Adams, and Z. A. Cohn, “Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen,” Journal of Experimental Medicine, vol. 141, no. 4, pp. 804–820, 1975. View at: Google Scholar
  4. R. M. Steinman and Z. A. Cohn, “Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution,” The Journal of Experimental Medicine, vol. 137, no. 5, pp. 1142–1162, 1973. View at: Publisher Site | Google Scholar
  5. R. M. Steinman and Z. A. Cohn, “Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro,” The Journal of Experimental Medicine, vol. 139, no. 2, pp. 380–397, 1974. View at: Publisher Site | Google Scholar
  6. R. M. Steinman, D. S. Lustig, and Z. A. Cohn, “Identification of a novel cell type in peripheral lymphoid organs of mice. 3. Functional properties in vivo,” Journal of Experimental Medicine, vol. 139, no. 6, pp. 1431–1445, 1974. View at: Publisher Site | Google Scholar
  7. M. Merad, P. Sathe, J. Helft, J. Miller, and A. Mortha, “The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting,” Annual Review of Immunology, vol. 31, pp. 563–604, 2013. View at: Publisher Site | Google Scholar
  8. K. Shortman and Y.-J. Liu, “Mouse and human dendritic cell subtypes,” Nature Reviews Immunology, vol. 2, no. 3, pp. 151–161, 2002. View at: Publisher Site | Google Scholar
  9. K. Shortman and S. H. Naik, “Steady-state and inflammatory dendritic-cell development,” Nature Reviews Immunology, vol. 7, no. 1, pp. 19–30, 2007. View at: Publisher Site | Google Scholar

Copyright © 2016 Silvia Beatriz Boscardin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Download other formatsMore
 Order printed copiesOrder
Views1430
Downloads676
Citations

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.