Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model

Figure 3

Localization of CD8+ T cells in hen ovaries with or without tumors. (a) Normal ovary showing CD8+ T cells. (b-c) Ovarian tumors at early and late stages showing more CD8+ T cells in tumor stroma. Few CD8+ T cells are seen to invade the tumor. Although influx of CD8+ T cells into the stroma increased with OVCA progression, intratumoral population of CD8+ T cells did not increase. Black and red arrows indicate examples of stromal and intratumoral CD8+ T cells, respectively. Dotted lines indicate the tumor. G and T: granulosa and theca of follicle (F); S: stroma; Tu: tumor; 40x.

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