Research Article

The Effect of Histological CD20-Positive B Cell Infiltration in Acute Cellular Rejection on Kidney Transplant Allograft Survival

Table 2

Patient baseline characteristics stratified by CD20 staining.

CharacteristicsCD20-negative
()
CD20-positive
()
value

Sex (male/female)54/2994/390.387
Age at transplantation (years)0.332
Warm ischemia time (min)0.657
Cold ischemia time (min)0.792
Donor type0.863
 Living17 (20.5%)26 (19.5%)
 Deceased66 (79.5%)107 (80.1%)
Primary disease0.445
 Chronic nephritis75 (90.4%)119 (89.5%)
 AKPD6 (7.2%)5 (3.8%)
 Diabetic nephropathy0 (0)2 (1.5%)
 Gouty nephropathy0 (0)2 (1.5%)
 Hereditary nephropathy0 (0)2 (1.5%)
 Others2 (2.4%)3 (2.2%)
Number of HLA mismatches0.468
Induction regimen0.498
 CD25 monoclonal antibody35 (42.2%)46 (34.6%)
 ATG/OKT34 (4.8%)9 (6.8%)
 None44 (53.0%)78 (58.6%)
PRA > 10% – number (%)
 After transplant4 (4.8%)2 (1.5%)0.149
 At rejection3 (3.6%)5 (3.8%)0.956
Prerejection immunosuppressant arms0.230
 FK506 + MMF +Pred53 (63.9%)76 (57.1%)
 CSA + MMF + Pred27 (32.5%)53 (39.8%)
 Rapamycin + MMF + Pred1 (1.2%)2 (1.5%)
 CSA + rapamycin + Pred2 (2.4%)0
 CSA + AZA + Pred0 (0)2 (1.5%)
Median days to ACR (range) (days)29 (3–3878)142 (3–3398)0.016

PRA, panel reactive antibody; AZA, azathioprine; CSA, cyclosporine; FK506, tacrolimus; MMF, mycophenolate mofetil; PRED, prednisone.