Journal of Immunology Research / 2016 / Article / Fig 5

Research Article

Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma

Figure 5

Tumor regression observed in EC9706 xenografts treated with different ways and the protein expressions of p70S6K and p-p70S6K in xenografts of each group. (a) Tumor volumes from the xenografts of each group were assessed every other day, and the results were expressed as means ± SE (mm3). The tumor growth of each treated group became slow, in which group treated with p70S6K siRNA combined with rapamycin was the slowest. (b) Tumors from the xenografts treated with different ways for two and a half weeks. (c) The protein expression of p70S6K and p-p70S6K in EC9706 xenografts analyzed by Western blot. (d) Semiquantitative values from three independently repeated experiments, which were statistically analyzed by densitometry using software Image J (NIH, USA), are expressed as means ± SD. , compared to control group. GAPDH was used as loading control.

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