Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Groups</td><td class="align_center">Animal weight (g)</td><td class="align_center">Volume before therapy (mm<sup>3</sup>)</td><td class="align_center">Volume after therapy (mm<sup>3</sup>)</td><td class="align_center">Inhibition rate (%)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Control</td><td class="align_center">18.80 ± 1.92</td><td class="align_center">82.68 ± 11.94</td><td class="align_center">1907.86 ± 326.00</td><td class="align_center">0</td></tr><tr><td class="align_left">Rapamycin</td><td class="align_center">20.07 ± 1.50</td><td class="align_center">63.12 ± 23.18</td><td class="align_center">546.62 ± 94.53</td><td class="align_center">70.35<svg height="10.0793pt" id="M27" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -10.0295 6.44358 10.0793" width="6.44358pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 104C274 83 290 61 320 49C345 61 366 83 376 104C356 148 343 173 339 224C381 195 396 171 424 132C447 130 474 133 499 152Z" id="g14-43"></path><glyph.data ascent="3452" descent="-2858" horiz-adv-x="640" vert-adv-y="640"></glyph.data></g></svg></td></tr><tr><td class="align_left">p70S6K siRNA</td><td class="align_center">19.54 ± 0.63</td><td class="align_center">87.99 ± 9.08</td><td class="align_center">1658.72 ± 159.58</td><td class="align_center">13.06</td></tr><tr><td class="align_left">siRNA + Rapa</td><td class="align_center">20.12 ± 1.28</td><td class="align_center">61.14 ± 15.42</td><td class="align_center">67.03 ± 33.88<svg height="10.0793pt" id="M28" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -10.0295 6.44358 10.0793" width="6.44358pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 328 499 359C477 375 447 382 424 380C396 342 380 317 338 288C342 339 356 364 376 408C366 429 350 451 320 463C295 451 274 429 265 408C284 364 297 339 301 288C259 317 244 341 216 380C193 382 166 379 141 359C139 332 148 303 160 284C208 279 237 277 283 256C237 234 208 233 160 228C148 209 136 184 141 152C163 137 193 130 216 132C244 170 260 195 302 224C298 173 284 148 265 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Effects of rapamycin alone or combined with p70S6K siRNA on the growth of ESCC xenografts in nude mice (<svg height="8.32035pt" id="M26" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -8.11395 27.8368 8.32035" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="502" vert-adv-y="502"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,21.421,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg>).

Journal of Immunology Research

tab1

Table 1

Table 1: Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma 