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Journal of Immunology Research
Volume 2016 (2016), Article ID 8605134, 6 pages
http://dx.doi.org/10.1155/2016/8605134
Review Article

Immune Regulation and Antitumor Effect of TIM-1

1Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China
2Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China
3The Second People’s Hospital of Gansu Province, Lanzhou, Gansu 730000, China
4Department of Oncology, The 181st Hospital of PLA, Guilin, Guangxi 541002, China

Received 18 February 2016; Revised 10 April 2016; Accepted 28 April 2016

Academic Editor: Bin Zhang

Copyright © 2016 Peng Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.