Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil

Table 2

Genotypes and allele frequencies distribution of IL17A rs2275913 and IL17F rs763780 in Chagas disease patients and controls in a population from South and Southeast of Brazil.

Allele/genotype (%)	CD patients	CCC	Without; LVSD	With; LVSD	Mild/moderate LVSD	Severe; LVSD	Without CCC	Control
	IL17A G197A
G	369 (71.2)	297 (70.4)	159 (72.9)	138 (67.6)	72 (70.6)	66 (64.7)	72 (75.0)	235 (78.3)
A	149 (28.8)	125 (29.6)	59 (27.1)	66 (32.4)	30 (29.4)	36 (35.3)	24 (25.0)	65 (21.7)
GG	130 (50.2)	104 (49.3)	58 (53.2)	46 (45.1)	24 (47.0)	22 (43.1)	26 (54.2)	88 (58.7)
GA	109 (42.1)	89 (42.2)	43 (39.5)	46 (45.1)	24 (47.0)	22 (43.1)	20 (41.7)	59 (39.3)
AA	20 (7.7)	18 (8.5)	8 (7.3)	10 (9.8)	3 (6.0)	7 (13.8)	2 (4.1)	3 (2.0)
IL17F T7488C
T	484 (93.1)	394 (92.9)	207 (94.9)	187 (90.8)	97 (93.3)	90 (88.2)	90 (93.7)	282 (94.0)
C	36 (6.9)	30 (7.1)	11 (5.1)	19 (9.2)	7 (6.7)	12 (11.8)	6 (6.3)	18 (6.0)
TT	224 (86.2)	182 (85.8)	98 (89.9)	84 (81.6)	45 (86.5)	39 (76.5)	42 (87.5)	132 (88.0)
TC	36 (13.8)	30 (14.2)	11 (10.1)	19 (18.4)	7 (13.5)	12 (23.5)	6 (12.5)	18 (12.0)

CCC: patients with chronic Chagas cardiomyopathy; LVSD: left ventricular systolic dysfunction; Recessive model: AA versus GA + GG; OR: odds ratio; CI: confidence interval. Adjustment of the genotypic differences for the effect of age and gender was applied.
. OR = 1.46 and 95% CI = 1.05–2.05; CD patients versus controls.
= 0.021. OR = 1.52 and 95% CI = 1.08–2.15; CCC versus controls.
. OR = 1.73 and 95% CI = 1.15–2.59.With LVSD versus controls.
. OR = 1.97 and 95% CI = 1.20–3.21. Severe LVSD versus controls.
Recessive model: ; OR = 4.12; 95% CI = 1.20–14.13. CD patients versus controls.
Recessive model: ; OR = 4.67; 95% CI = 1.35–16.18. CCC versus controls.
Recessive model: ; OR = 5.73; 95% CI = 1.52–21.64. With LVSD versus controls.
Recessive model: ; OR = 8.18; 95% CI = 2.00–33.51. Severe LVSD versus controls.