Research Article

The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers

Table 14

Effect of NAC on blood DC levels in women with LLABCs.

Pathological respondersDC baseline levels (%)
value

GPRs + PPRs1.34 ± 0.30
GPRs + PPRs versus HFDsNS
GPRs1.64 ± 0.25
GPRs versus HFDNS
PPRs1.29 ± 0.25
PPRs versus HFDsNS

Pathological respondersDC post-NAC levels (%)
value

GPRs3.24 ± 1.62
GPRs versus HFDs0.024
PPRs2.17 ± 0.5
PPRs versus HFDsNS

NAC: neoadjuvant chemotherapy; LLABCs: large and locally advanced breast cancers; GPRs: good pathological responders (pCR or ≥90% reduction of invasive disease); PPRs: poor pathological responders (no response or <90% reduction of invasive disease); HFDs: healthy female donors; NS: nonsignificant; statistically significant.