The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers

Table 6

Alteration of tumour-infiltrating CD1a⁺ dendritic cells and CD66b⁺ neutrophils in breast tumours in women with LLABCs undergoing NAC.

Groups		Pre-NAC median (range)^(3)	Post-NAC median (range)^(3)	value^(4) (pre- versus post-NAC)
CD1a^+	Intratumoural infiltration ()	3.5 (0–104)	0 (0–2)	0.001
	Peritumoural infiltration ()	1.5 (0–16)	1 (0–7)	0.184
CD66b^+	Intratumoural infiltration ()	1 (0–53)	4.5 (0–50)	0.125
	Peritumoural infiltration ()	1.5 (0–71)	2.5 (0–82)	0.470

LLABCs: large and locally advanced breast cancers; NAC: neoadjuvant chemotherapy; ⁽³⁾cell count in 400x HPF; ⁽⁴⁾Wilcoxon signed-rank test; statistically significant.