The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis

Table 2

KEGG pathway analysis of downregulation genes associated with glioma.

Term	Pathway	Gene count	%	value	Genes
hsa04010	MAPK signaling pathway	22	0.023	6.35E − 05	MEF2C, BRAF, MAP2K1, NLK, MAP2K4, TP53, PPP3R1, PTPRR, CACNG3, PRKCG, PRKCB, CDC42, RASGRF2, MAPK9, MAPK8IP3, STMN1, PAK1, PRKACB, RAPGEF2, CACNA1C, DUSP7, CACNA1B
hsa04144	Endocytosis	20	0.021	5.98E − 04	SH3GL3, PARD3, CLTB, PSD3, PIP5K1C, HLA-E, EPS15, RAB11FIP4, MVB12A, CDC42, AP2A2, RAB31, SH3GLB2, NEDD4, ARPC5L, ARF3, KIAA1033, NEDD4L, IQSEC1, F2R
hsa04921	Oxytocin signaling pathway	15	0.015	5.25E − 04	MEF2C, ADCY2, CAMK1G, MAP2K1, PPP1R12B, PPP3R1, CACNG3, PRKCG, CAMKK1, PRKCB, CAMKK2, CAMK2B, GUCY1B3, PRKACB, CACNA1C
hsa04020	Calcium signaling pathway	14	0.014	0.0048	SLC8A1, ADCY2, PTGER3, CCKBR, PPP3R1, PRKCG, PRKCB, ATP2B1,PDE1A, CAMK2B, PRKACB, CACNA1C, CACNA1B, F2R
hsa05205	Proteoglycans in cancer	14	0.014	0.012	CDC42, WNT10B, HIF1A, MAP2K1, BRAF, ANK3, PPP1R12B, TP53, PRKCG, CAMK2B, PAK1, PRKACB, TIMP3, PRKCB
hsa00230	Purine metabolism	13	0.013	0.0109	NME4, ADSS, GDA, ADCY2, POLR1E, RRM2, PDE1A, PRIM2, AK5, GUCY1B3, ENTPD4, HPRT1, GART
hsa04024	cAMP signaling pathway	13	0.013	0.0253	PPARA, ADCY2, PTGER3, BRAF, MAP2K1, ATP2B1, NPY, MAPK9, CAMK2B, PRKACB, PAK1, CACNA1C, F2R
hsa04810	Regulation of actin cytoskeleton	13	0.013	0.0387	GNA13, PAK6, CDC42, ENAH,MAP2K1, BRAF, ARHGEF6, PPP1R12B, ARPC5L, WASF2, PIP5K1C, PAK1, F2R