Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2017, Article ID 1747030, 9 pages
https://doi.org/10.1155/2017/1747030
Research Article

De Novo Donor-Specific HLA Antibodies Developing Early or Late after Transplant Are Associated with the Same Risk of Graft Damage and Loss in Nonsensitized Kidney Recipients

1Nephrology, Dialysis and Transplantation Unit, IRCCS Istituto G. Gaslini, Genova, Italy
2Clinical Nephrology Unit and Transplant Immunology Research Laboratory, Department of Internal Medicine, University of Genova and IRCCS San Martino University Hospital IST, Genova, Italy
3Transplantation Immunology, IRCCS Fondazione Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
4Pediatric Hematology/Oncology and Cell Factory, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
5Vascular and Endovascular Unit and Kidney Transplant Surgery Unit, University of Genova, IRCCS San Martino University Hospital IST, Genova, Italy
6Biometry and Statistics Service, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy

Correspondence should be addressed to Fabrizio Ginevri; gro.inilsag@irvenigoizirbaf

Received 23 December 2016; Revised 27 January 2017; Accepted 13 February 2017; Published 6 March 2017

Academic Editor: Senthami R. Selvan

Copyright © 2017 Michela Cioni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. I. Terasaki, “Humoral theory of transplantation,” American Journal of Transplantation, vol. 3, no. 6, pp. 665–673, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. Z. M. El-Zoghby, M. D. Stegall, D. J. Lager et al., “Identifying specific causes of kidney allograft loss,” American Journal of Transplantation, vol. 9, no. 3, pp. 527–535, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. T. B. Dunn, H. Noreen, K. Gillingham et al., “Revisiting traditional risk factors for rejection and graft loss after kidney transplantation,” American Journal of Transplantation, vol. 11, no. 10, pp. 2132–2143, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. R. S. Gaston, J. M. Cecka, B. L. Kasiske et al., “Evidence for antibody-mediated injury as a Major determinant of late kidney allograft failure,” Transplantation, vol. 90, no. 1, pp. 68–74, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Loupy, G. S. Hill, and S. C. Jordan, “The impact of donor-specific anti-HLA antibodies on late kidney allograft failure,” Nature Reviews Nephrology, vol. 8, no. 6, pp. 348–357, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. L. G. Hidalgo, P. M. Campbell, B. Sis et al., “De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure,” American Journal of Transplantation, vol. 9, no. 11, pp. 2532–2541, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. P.-C. Lee, L. Zhu, P. I. Terasaki, and M. J. Everly, “HLA-specific antibodies developed in the first year posttransplant are predictive of chronic rejection and renal graft loss,” Transplantation, vol. 88, no. 4, pp. 568–574, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. Mao, P. I. Terasaki, J. Cai et al., “Extremely high association between appearance of HLA antibodies and failure of kidney grafts in a five-year longitudinal study,” American Journal of Transplantation, vol. 7, no. 4, pp. 864–871, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Lachmann, P. I. Terasaki, K. Budde et al., “Anti-human leukocyte antigen and donor-specific antibodies detected by luminex posttransplant serve as biomarkers for chronic rejection of renal allografts,” Transplantation, vol. 87, no. 10, pp. 1505–1513, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. P. M. Kimball, M. A. Baker, M. B. Wagner, and A. King, “Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection,” Kidney International, vol. 79, no. 10, pp. 1131–1137, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Wiebe, I. W. Gibson, T. D. Blydt-Hansen et al., “Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant,” American Journal of Transplantation, vol. 12, no. 5, pp. 1157–1167, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Ginevri, A. Nocera, P. Comoli et al., “Posttransplant de novo donor-specific HLA antibodies identify pediatric kidney recipients at risk for late antibody-mediated rejection,” American Journal of Transplantation, vol. 12, no. 12, pp. 3355–3362, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Willicombe, P. Brookes, R. Sergeant et al., “De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy,” Transplantation, vol. 94, no. 2, pp. 172–177, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. J. M. Devos, A. O. Gaber, R. J. Knight et al., “Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation,” Kidney International, vol. 82, no. 5, pp. 598–604, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. J. Everly, L. M. Rebellato, C. E. Haisch et al., “Incidence and impact of de Novo donor-specific alloantibody in primary renal allografts,” Transplantation, vol. 95, no. 3, pp. 410–417, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. B. D. Tait, C. Süsal, H. M. Gebel et al., “Consensus guidelines on the testing and clinical management issues associated with HLA and Non-HLA antibodies in transplantation,” Transplantation, vol. 95, no. 1, pp. 19–47, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Calp-Inal, M. Ajaimy, M. L. Melamed et al., “The prevalence and clinical significance of C1q-binding donor-specific anti-HLA antibodies early and late after kidney transplantation,” Kidney International, vol. 89, no. 1, pp. 209–216, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. G. J. Schwartz, A. Muñoz, M. F. Schneider et al., “New equations to estimate GFR in children with CKD,” Journal of the American Society of Nephrology, vol. 20, no. 3, pp. 629–637, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Shaffi, K. Uhlig, R. D. Perrone et al., “Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients,” American Journal of Kidney Diseases, vol. 63, no. 6, pp. 1007–1018, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Sis, M. Mengel, M. Haas et al., “Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups,” American Journal of Transplantation, vol. 10, no. 3, pp. 464–471, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Haas, B. Sis, L. C. Racusen et al., “Banff 2013 meeting report: inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions,” American Journal of Transplantation, vol. 14, no. 2, pp. 272–283, 2014. View at Publisher · View at Google Scholar
  22. A. Tagliamacco, M. Cioni, P. Comoli et al., “DQ molecules are the principal stimulators of de novo donor-specific antibodies in nonsensitized pediatric recipients receiving a first kidney transplant,” Transplant International, vol. 27, no. 7, pp. 667–673, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Visentin, M. Vigata, S. Daburon et al., “Deciphering complement interference in anti-human leukocyte antigen antibody detection with flow beads assays,” Transplantation, vol. 98, no. 6, pp. 625–631, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. A. R. Tambur, N. D. Herrera, K. M. K. Haarberg et al., “Assessing antibody strength: comparison of MFI, C1q, and titer information,” American Journal of Transplantation, vol. 15, no. 9, pp. 2421–2430, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Nocera, M. Cioni, A. Tagliamacco et al., “Serum complement inactivation unveiled prepregnancy donor-specific HLA antibodies leading to postpartum kidney graft loss,” Transplant International, vol. 28, no. 5, pp. 623–625, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Loupy, C. Lefaucheur, D. Vernerey et al., “Complement-binding anti-HLA antibodies and kidney-allograft survival,” New England Journal of Medicine, vol. 369, no. 13, pp. 1215–1226, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. P. Comoli, M. Cioni, A. Tagliamacco et al., “Acquisition of C3d-binding activity by de novo donor-specific HLA antibodies correlates with graft loss in nonsensitized pediatric kidney recipients,” American Journal of Transplantation, vol. 16, no. 7, pp. 2106–2116, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. G. N. de Graav, M. Dieterich, D. A. Hesselink et al., “Follicular T helper cells and humoral reactivity in kidney transplant patients,” Clinical and Experimental Immunology, vol. 180, no. 2, pp. 329–340, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Tagliamacco, R. Biticchi, G. Garibotto, F. Ginevri, and A. Nocera, “Gene expression in highly sensitized dialysis patients waiting for a kidney transplant: a real-time PCR analysis,” Transplant Immunology, vol. 33, no. 3, pp. 166–167, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Sicard, S. Ducreux, M. Rabeyrin et al., “Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss,” Journal of the American Society of Nephrology, vol. 26, no. 2, pp. 457–467, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Viglietti, A. Loupy, D. Vernerey et al., “Value of donor-specific anti-HLA antibody monitoring and characterization for risk stratification of kidney allograft loss,” Journal of the American Society of Nephrology, vol. 28, no. 2, pp. 702–715, 2017. View at Publisher · View at Google Scholar
  32. D. S. Ramon, Y. Huang, L. Zhao et al., “Use of complement binding assays to assess the efficacy of antibody mediated rejection therapy and prediction of graft survival in kidney transplantation,” Human Immunology, vol. 78, no. 2, pp. 57–63, 2017. View at Publisher · View at Google Scholar
  33. B. R. Slegtenhorst, F. J. M. F. Dor, A. Elkhal et al., “Mechanisms and consequences of injury and repair in older organ transplants,” Transplantation, vol. 97, no. 11, pp. 1091–1099, 2014. View at Publisher · View at Google Scholar · View at Scopus