Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients

Table 7

Cytokine profile of different phases of erysipelas infection.

	Binary logistic regression of cytokines comparing values in control to values in both phases of infection			95% confidence interval of cytokine values		Pearson’s coeff (K) between both phases
	Phase		Average cytokine value	Lower	Higher
Group 1
IL-1β	Acute	0.046	1.516	1.008	2.280	0.436
	Convalescent	0.158	1.419	.873	2.308
CCL11	Acute	0.002	.963	.941	.987	0.432
	Convalescent	0.962	.000	.000	7.555E + 216
IL-2Rα	Acute	0.009	1.072	1.017	1.130	0.495
	Convalescent	0.055	1.055	.999	1.115
HGF	Acute	0.024	1.011	1.001	1.021	0.296
	Convalescent	0.099	1.010	.998	1.023
CXCL9	Acute	0.016	1.015	1.003	1.028	0.436
	Convalescent	0.050	1.014	1.000	1.028
TRAIL	Acute	0.049	1.053	.999	1.109	0.677
	Convalescent	0.091	1.043	.993	1.095
Group 2
IL-7	Acute	0.107	2.744	.805	9.357	0.340
	Convalescent	0.045	3.741	1.031	13.567
IL-8	Acute	0.107	1.010	.998	1.023	0.340
	Convalescent	0.045	1.013	1.000	1.026
PDGF-BB	Acute	0.072	1.010	.999	1.022	0.504
	Convalescent	0.044	1.016	1.000	1.031
CCL4	Acute	0.052	1.579	.996	2.505	0.584
	Convalescent	0.044	1.016	1.000	1.031
CXCL12	Acute	0.964	1.000	.988	1.013	−0.186
	Convalescent	0.031	.980	.961	.998
Group 3
IL-5	Acute	0.007	178.828	4.035	7925.340	0.001
	Convalescent	0.037	61.093	1.289	2896.100
IL-6	Acute	0.007	1.053	1.014	1.094	0.500
	Convalescent	0.037	1.042	1.003	1.083
IL-9	Acute	0.017	2.053	1.136	3.711	0.470
	Convalescent	0.033	2.641	1.082	6.449
IL-10	Acute	0.017	1.075	1.013	1.140	0.470
	Convalescent	0.033	1.102	1.008	1.205
IL-13	Acute	0.013	1.092	1.019	1.171	0.574
	Convalescent	0.012	1.091	1.019	1.169
IL-15	Acute	0.006	1.119	1.034	1.211	0.420
	Convalescent	0.001	1.157	1.058	1.265
IL-17	Acute	0.018	1.094	1.015	1.178	0.442
	Convalescent	0.020	1.106	1.016	1.204
G-CSF	Acute	0.019	1.153	1.024	1.297	0.607
	Convalescent	0.015	1.134	1.025	1.255
GM-CSF	Acute	0.014	1.014	1.003	1.025	−0.167
	Convalescent	0.031	1.011	1.001	1.021
CXCL10	Acute	0.011	1.005	1.001	1.009	0.296
	Convalescent	0.040	1.004	1.000	1.008
CCL2	Acute	0.035	1.225	1.014	1.481	0.171
	Convalescent	0.010	1.337	1.071	1.671
CCL3	Acute	0.035	675657538.718	4.009	113865012433100720.000
	Convalescent	0.010	4221003831075.196	914.082	19491539205039153000000.000	0.171
VEGFr	Acute	0.019	1.036	1.006	1.067	0.767
	Convalescent	0.040	1.036	1.002	1.071
MIF	Acute	0.027	1.017	1.002	1.032	0.360
	Convalescent	0.019	1.021	1.003	1.039
SCF	Acute	0.020	1.058	1.009	1.110	0.386
	Convalescent	0.006	1.124	1.034	1.222
SCGF-β	Acute	0.039	1.003	1.000	1.006	0.293
	Convalescent	0.021	1.003	1.000	1.006
Group 4
IL-1ra	Acute	0.323	1.022	.979	1.067	0.363
	Convalescent	0.549	1.015	.966	1.068
IL-2	Acute	0.085	1.679	.930	3.030	0.108
	Convalescent	0.068	1.677	.963	2.922
IL-4	Acute	0.093	2.670	.850	8.392	0.131
	Convalescent	0.380	1.618	.552	4.743
IL12 (p70)	Acute	0.093	1.035	.994	1.077	0.237
	Convalescent	0.634	.989	.945	1.035
FGF	Acute	0.116	1.010	.998	1.022	0.792
	Convalescent	0.421	1.005	.993	1.017
IFN-γ	Acute	0.093	1.003	.999	1.007	−0.010
	Convalescent	0.764	1.001	.997	1.005
CCL5	Acute	0.106	1.004	.999	1.009	−0.235
	Convalescent	0.059	1.007	1.000	1.015
TNF-α	Acute	0.325	1.030	.971	1.092	0.825
	Convalescent	0.092	1.123	.981	1.284
IL-3	Acute	0.086	1.020	.997	1.043	0.179
	Convalescent	0.647	1.005	.984	1.027
IL12 (p40)	Acute	0.650	1.002	.993	1.012	0.244
	Convalescent	0.606	.998	.988	1.007
IL-16	Acute	0.323	1.010	.990	1.031	−0.205
	Convalescent	0.688	.996	.975	1.017
IL-18	Acute	0.697	1.013	.950	1.080	0.163
	Convalescent	0.556	1.020	.956	1.088
CCL27	Acute	0.299	1.009	.992	1.027	0.428
	Convalescent	0.209	1.015	.992	1.038
CXCL1	Acute	0.108	1.162	.968	1.397	0.005
	Convalescent	0.252	1.167	.896	1.521
IFN-α2	Acute	0.157	1.092	.967	1.233	0.264
	Convalescent	0.502	1.042	.924	1.174
CCL7	Acute	0.269	.983	.953	1.014	0.230
	Convalescent	0.120	.967	.927	1.009
β-NGF	Acute	0.056	7.255	.949	55.459	0.071
	Convalescent	0.489	2.543	.181	35.767

Column p indicates the statistical difference of cytokine values between the respective phases and the cytokine values found in the controls. (Group 1) cytokine values in studied patients in the acute phase of the infection significantly differed from values observed in the controls (). During the convalescent stage, the values of the cytokines recovered to levels observed in the healthy patients (). Coefficient of changes in cytokine values, except in HGF, of the patients between the two phases was high (). (Group 2) cytokine values in the studied patients did not differ from values observed in the healthy participants () but differed from the values in the controls during the convalescent stage (). Coefficient of changes in cytokine values of PDGF-BB and CCL4 of the patients between the two phases was high (). (Group 3) cytokine levels in the acute and convalescent phases significantly differed from the values of these cytokines in healthy participants (). Similar changes between both phases in the patients were observed in IL-6, IL-9, IL-10, IL-13, IL-15, IL17, and G-CSF (). (Group 4) these include cytokines which had no statistically significant difference in values between both stages in the values of the studied patients and the healthy participants (). However, FGF, TNFα, and CCL27 had a similar change in level in the patients.