Polymorphisms of IL12RB2 May Affect the Natural History of Primary Biliary Cholangitis: A Single Centre Study

Table 2

Distribution of IL12RB2 polymorphisms (rs3790567, rs6679356) in PBC patients and control subjects.

SNP	Genotype	Count of alleles/genotypes		Fisher exact; value		OR
		Control () (%)	PBC () (%)
rs3790567	A/G	107/409 (20.7/79.3)	186/426 (30.4/69.6)	0.0009	11.5	1.7 [1.3–2.2]
	AA	11 (4.2)	29 (9.5)	0.02	5.8	2.3 [1.1–4.8]
	AG	85 (33)	128 (42)	0.02	4.7	1,5 [1.0–2.1]
	GG	162 (62.8)	149 (48.5)	0.0009	11.3	0.6 [0.4–0,8]
rs6679356	C/T	89/427 (17.2/82.8)	153/459 (25/75)	0.002	9.5	1.6 [1.2–2.1]
	CC	11 (4.2)	22 (7.2)	NS	2.2	1,7 [0.8–3.6]
	CT	67 (26)	109 (35.6)	0.01	6.1	1,6 [1.1–2.3]
	TT	180 (69.8)	175 (57.2)	0.03	5.1	0,6 [0.4–0.8]