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Journal of Immunology Research
Volume 2017, Article ID 2314813, 8 pages
https://doi.org/10.1155/2017/2314813
Review Article

Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence

1Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow 119991, Russia
2Faculty of Pediatrics, Sechenov First Moscow State Medical University, Moscow 119991, Russia
3Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia

Correspondence should be addressed to Andrey A. Zamyatnin Jr.; ur.usm.yksrezoleb@taymaz

Received 29 November 2016; Revised 15 January 2017; Accepted 30 January 2017; Published 20 February 2017

Academic Editor: David Bernardo

Copyright © 2017 Lyudmila V. Savvateeva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of dietary gluten from some cereals mainly in individuals carrying the HLA-DQ2 and/or HLA-DQ8 haplotypes. As an autoimmune disease, CD is manifested in the small intestine in the form of a progressive and reversible inflammatory lesion due to immune response to self-antigens. Indeed, CD is one of the most challenging medicosocial problems in current gastroenterology. At present, the global CD prevalence is estimated at approximately 1% based on data sent from different locations and available CD screening strategies used. However, it is impossible to estimate global CD prevalence without all the data from the world, including Russia. In this review, we summarize the data on the incidence and prevalence of CD across geographically distinct regions of Russia, which are mostly present in local Russian scientific sources. Our conclusion is that the situation of CD prevalence in Russia is higher than is commonly believed and follows global tendencies that correspond to the epidemiologic situation in Europe, America, and Southwest Asia.