Sirtuin 2 Regulates Microvascular Inflammation during Sepsis
(a) Leukocyte adhesion with SIRT2 modification. Leukocyte adhesion in the small intestinal microcirculation in sepsis groups was significantly increased versus that in the respective sham groups ( in each group). Leukocyte adhesion in SIRT2KO sepsis mice was significantly increased versus that in WT sepsis; leukocyte adhesion in SIRT2KI sepsis mice was significantly decreased versus that in WT sepsis mice. Leukocyte adhesion in SIRT2KI sepsis mice was significantly decreased versus that in SIRT2KO sepsis mice. Leukocyte adhesion in WT, SIRT2KO, and SIRT2KI sham mice were not significantly different from each other. versus respective sham; # versus WT sepsis using Tukey’s post hoc analysis; error bars: sem. (b) shows SIRT2 expression in peritoneal cells from WT, SIRT2KO, and SIRT2KI mice with CLP. As expected, SIRT2 expression in the peritoneal cell in SIRT2KO mice was significantly lower than that in WT while that in SIRT2KI mice was significantly higher compared to that in WT mice.