Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2017 (2017), Article ID 2738784, 9 pages
https://doi.org/10.1155/2017/2738784
Research Article

Comparison between the HLA-B58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions

1Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
2School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand
3Pharmacy Unit, Udon Thani Hospital, Udon Thani, Thailand
4Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand
5Pharmacy Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
6Department of Pathology, Division of Pharmacogenomics and Personalized Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
7Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
8Pharmacy Unit, Police General Hospital, Bangkok, Thailand
9Pharmacy Department, Khon Kaen Hospital, Khon Kaen, Thailand

Correspondence should be addressed to Wichittra Tassaneeyakul; moc.liamg@lukayeenassat.arttihciw

Received 24 July 2017; Accepted 8 November 2017; Published 17 December 2017

Academic Editor: Ethan M. Shevach

Copyright © 2017 Niwat Saksit et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions. The strong association between the HLA-B58 : 01 allele and allopurinol-induced SCARs is well recognized. Screening for HLA-B58 : 01 allele before prescribing allopurinol in some populations has been recommended. Several single-nucleotide polymorphisms (SNPs) in chromosome 6 have been found to be tightly linked with the HLA allele, and these SNPs have been proposed as surrogate markers of the HLA-B58 : 01 allele. This study aimed to evaluate the association between three SNPs in chromosome 6 and allopurinol-induced SCARs in a Thai population. The linkage disequilibrium between the HLA-B58 : 01 allele and these SNPs was also evaluated. Results showed that three SNPs including rs9263726, rs2734583, and rs3099844 were significantly associated with allopurinol-induced SCARs but with a lower degree of association when compared with the HLA-B58 : 01 allele. The sensitivity, specificity, PPV, and NPV of these SNPs were comparable to those of the HLA-B58 : 01 allele. Although detection of the SNP is simpler and less expensive compared with that of the HLA-B58 : 01 allele, these SNPs were not perfectly linked with the HLA-B58 : 01 allele. Screening using these SNPs as surrogate markers of the HLA-B58 : 01 allele to avoid SCARs prior to allopurinol administration needs caution because of their imperfect linkage with the HLA-B58 : 01 allele.