Comparison between the HLA-B58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions

Table 1

Demographic and clinical characteristics of allopurinol-induced SCARs and tolerant control patients.

Characteristic data		DRESS ()	SJS/TEN ()	SCARs ()	Control ()
Age (year)	Mean (SD)	65 (14)	65 (12)	65 (12)	64 (12)
	Median (range)	68 (28–82)	68 (38–84)	68 (28–84)	66 (29–91)
Gender	Female; n (%)	10 (43.48)	40 (54.79)	50 (52.08)	49 (25.39)
Onset of SCARs (day)	Mean (SD)	29 (13)	19 (11)	21 (13)	—
	Median (range)	30 (10–60)	18 (2–60)	20 (2–60)	—
Allopurinol dose (mg)	Mean (SD)	171 (78)	182 (106)	179 (99)	194 (90)
	Median (range)	200 (100–300)	100 (50–600)	100 (50–600)	200 (100–600)
Indication of allopurinol	Hyperuricemia; n (%)	11 (47.83)	13 (17.81)	24 (25.00)	3 (1.55)
	Gouty arthritis; n (%)	12 (52.17)	60 (82.19)	72 (75.00)	190 (98.45)
Baseline kidney function
Blood urine nitrogen (mg/dL)	n	14	26	40	129
	Mean (SD)	29.79 (21.14)	24.85 (20.09)	26.58 (20.33)	18.63 (10.40)
	Median (range)	21.35 (11.00–80.00)	18.50 (10.00–105.00)	21.00 (10.00–105.00)	16.20 (3.00–70.00)
Serum creatinine (mg/dL)	n	19	65	84	174
	Mean (SD)	2.20 (2.20)	1.54 (1.05)	1.69 (1.40)	1.47 (1.46)
	Median (range)	1.40 (0.90–9.60)	1.30 (0.50–8.82)	1.30 (0.50–9.60)	1.20 (0.70–14.80)
Estimated glomerular filtration rate (eGFR) (mL/min/1.73 m^2)^a	n	19	65	84	174
	Mean (SD)	44.05 (21.99)	48.61 (21.95)	47.58 (21.91)	58.01 (20.41)
	Median (range)	46.00 (6.54–88.61)	45.27 (4.62–127.17)	45.65 (4.62–127.17)	57.45 (3.12–112.49)
	eGFR < 30.00; n (%)	4 (17.39)	14 (19.18)	18 (21.43)	13 (7.47)
	30.00 ≤ eGFR < 60.00; n (%)	11 (47.83)	37 (50.68)	48 (57.14)	78 (44.83)
	eGFR ≥ 60.00; n (%)	4 (17.39)	14 (19.18)	18 (21.43)	83 (47.70)

^aeGFR: estimated glomerular filtration rate (expressed as mL/min/1.73 m²) calculated by Modification of Diet in Renal the Disease (MDRD) study equation [39]. Indicated significant difference between case and tolerant control. value < 0.05, value < 0.01, value < 0.001, value < 0.0001, and value < 0.00001.