Comparison between the HLA-B58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions

Table 2

Univariate analysis of the association between HLA-B58 : 01 allele and SNPs with allopurinol-induced SCARs.

Allele/SNPs		Control ()	DRESS ()		SJS/TEN ()		SCARs ()
		n (%)	n (%)	OR; [95% CI]; Pc-value	n (%)	OR; [95% CI]; Pc-value	n (%)	OR; [95% CI]; Pc-value
HLA-B58 : 01	Negative	170 (88.08)	2 (8.70)	Reference	4 (5.48)	Reference	6 (6.25)	Reference
	Positive	23 (11.92)	21 (91.30)	77.61; [17.07–352.85]; 7.12 × 10^−8	69 (94.52)	127.50; [42.53–382.27]; 1.99 × 10^−17	90 (93.75)	110.87; [43.57–282.15]; 2.05 × 10^−22
rs9263726 (G/A)	Negative (GG)	159 (82.38)	4 (17.39)	Reference	5 (6.85)	Reference	9 (9.38)	Reference
	Positive (GA/AA)	34 (17.62)	19 (82.61)	22.21; [7.10–69.46]; 3.91 × 10^−7	68 (93.15)	63.60; [23.85–169.56]; 4.22 × 10^−16	87 (90.63)	45.21; [20.73–98.60]; 3.92 × 10^−21
rs2734583 (T/C)	Negative (TT)	166 (86.01)	2 (8.70)	Reference	7 (9.59)	Reference	9 (9.37)	Reference
	Positive (TC/CC)	27 (13.99)	21 (91.30)	64.56; [14.31–291.16]; 2.35 × 10^−7	66 (90.41)	57.97; [24.07–139.60]; 5.51 × 10^−19	87 (90.63)	59.43; [26.76–131.97]; 4.24 × 10^−23
rs3099844 (C/A)	Negative (CC)	164 (84.97)	2 (8.70)	Reference	7 (9.59)	Reference	9 (9.38)	Reference
	Positive (CA/AA)	29 (15.03)	21 (91.30)	59.38; [13.21–266.97]; 4.04 × 10^−7	66 (90.41)	53.32; [22.26–127.71]; 1.82 × 10^−18	87 (90.63)	54.67; [22.77–120.66]; 1.58 × 10^−22
SNPs haplotypes (rs9263726-rs2734583-rs3099844)	GG-TT-CC	156 (80.83)	2 (8.70)	Reference	4 (5.48)	Reference	6 (6.25)	Reference
	GA-TC-CA	24 (12.44)	16 (69.57)	52.00; [11.24–240.51]; 1.17 × 10^−6	61 (83.56)	99.13; [33.03–297.52]; 9.90 × 10^−16	77 (80.21)	83.42; [32.74–212.55]; 7.43 × 10^−20

Pc-value: Bonferroni-corrected value, calculated by multiplying value by 4 which is the number of detected SNPs.