The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

Table 1

Transplant cases: HLA-DR and HLA-DQ mismatches and DSA.

Tx ID	Recipient HLA typing	HLA allele mismatches	Mismatch ID	DSA
13; 3 mismatches; 2 DSAs	DRB04:05	DRB11:04	1	No
	DRB14:01
	DQB03:02	DQB03:01	2	Yes
	DQB05:03
	DQA01:01	DQA05:05	3	Yes
	DQA03:01
18; 3 mismatches; 2 DSAs	DRB11:01	DRB07:01	4	No
	DRB16:01
	DQB03:01	DQB02:02	5	Yes
	DQB05:02
	DQA01:02	DQA02:01	6	Yes
	DQA05:05
21; 4 mismatches; 4 DSAs	DRB07:01	DRB08:01	7	Yes
	DQB02:01	DQB03:01	8	Yes
	DQB02:02	DQB03:03	9	Yes
	DQA02:01	DQA06:01	10	Yes
22; 5 mismatches; 3 DSAs	DRB11:01	DRB07:01	11	No
	DRB14:07	DRB15:01	12	No
	DQB05:02	DQB02:02	13	Yes
	DQB05:03	DQB06:02	14	Yes
	DQA01:01	DQA02:01	15	Yes
	DQA01:02
33; 5 mismatches; 3 DSAs	DRB11:01	DRB07:01	16	Yes
	DRB16:01	DRB13:01	17	No
	DQB03:01	DQB02:02	18	Yes
	DQB05:02	DQB06:04	19	No
	DQA01:02	DQA02:01	20	Yes
	DQA05:05
35; 5 mismatches; 3 DSAs	DRB04:03	DRB07:01	21	Yes
	DRB13:02	DRB15:01	22	No
	DQB03:02	DQB02:02	23	Yes
	DQB06:04	DQB06:03	24	No
	DQA01:02	DQA02:01	25	Yes
	DQA03:01

DSA: donor-specific HLA antibody.