The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

Table 2

HLA class II mismatch characteristics.

Mismatch ID	DSA	EpMS (ab, ot)	PIRCHE-II	HMS	EMS	AMS
1	No	4 (3, 1)	6	4.399	6.32	4
2	Yes	3 (1, 2)	8	4	4.749	4
3	Yes	8 (6, 2)	18	17.399	16	13
4	No	14 (4, 10)	9	12.499	14.229	16
5	Yes	9 (3, 6)	11	7.199	2.869	9
6	Yes	5 (2, 3)	9	5.499	10.969	9
7	Yes	16 (5, 11)	12	19.4	21.81	16
8	Yes	16 (9, 7)	12	25.499	19.1	19
9	Yes	15 (9, 6)	11	22.399	14.65	16
10	Yes	4 (3, 1)	12	19.899	20.79	10
11	No	13 (4, 9)	8	11.999	15.859	17
12	No	9 (1, 8)	7	14.3	15.43	11
13	Yes	12 (5, 7)	17	14.7	11.259	15
14	Yes	10 (2, 8)	13	3	1.03	7
15	Yes	12 (2, 10)	17	33.999	31.23	21
16	Yes	14 (4, 10)	9	12.499	14.229	16
17	No	6 (0, 6)	3	3.199	4.51	5
18	Yes	9 (3, 6)	11	7.199	2.869	9
19	No	6 (1, 5)	10	5.099	5.79	3
20	Yes	5 (2, 3)	9	5.499	10.969	9
21	Yes	11 (3, 8)	1	11.599	11.589	13
22	No	6 (1, 5)	3	10	10.03	8
23	Yes	8 (4, 4)	7	9	8.05	7
24	No	5 (2, 3)	2	0.9	0.529	3
25	Yes	4 (1, 3)	6	2	4.049	5

AMS: Amino acid mismatch score; DSA: donor-specific HLA antibody; EMS: electrostatic mismatch score; EpMS (ab, ot): eplet mismatch score (antibody verified and others); HMS: hydrophobicity mismatch score; PIRCHE-II: predicted indirectly recognizable HLA epitopes, HLA class II-presented.