Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis

Table 1

HLA haplotype associations with PBC.

Study	Population	HLA allele	value	OR (95% CI)
Susceptibility
Umemura et al. [26]	Japanese	DRB108:03-DQB106:01	0.000025	2.22 (1.53–3.20)
		DRB104:05-DQB104:01	0.044	1.38 (10.2–1.87)
Zhao et al. [27]	Chinese	DRB108:03-DQB106:01	<0.0001	3.17 (1.91–5.23)
		DRB107:01-DQB102:02	0.005	1.85 (1.20–2.83)
Donaldson et al. [28]	UK	DRB108:01-DQA10401-DQB104:02	0.0027	2.9
	Italian	DRB108:01-DQA10401-DQB104:02	0.0086	3.41
Protective
Umemura et al. [26]	Japanese	DRB113:02-DQB106:04	0.00093	0.27 (0.12–0.60)
		DRB111:01-DQB103:01	0.03	0.37 (0.15–0.88)
Zhao et al. [27]	Chinese	DRB112:02-DQB103:01	0.015	0.43 (0.22–0.86)
Donaldson et al. [28]	UK	DRB111:01-DQA105:01-DQB103:01	0.086	0.47
	Italian	DRB113:01-DQA101:03-DQB106:03	0.0041	0.28