Review Article

HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined

Table 2

Epitopes on intact antigens targeted by naturally occurring antibodies—partial list. Complete list in supplemental file.

Epitope numberDissociated antigen(s)Epitope siteEpitope numberDissociated antigen(s)Epitope site

5059A0101158V + 163R5073B76163L + 166D
201A243Q + 62G5075, 0302, 0303, 0304, 1402, 1802219W
3A23, A2465G5076Cw16193L
31A30, 3156R5077Cw17170G
5064A300217S + 76E5078Cw7273S
5066A6602149T5081Cw9, Cw10163L + 173K
5068A8056E+5085B8(67F) + 131R
406B270565Q + 69A + 80T5086Cw680K + 90D + (114D)
236B57, B5843P + 62G

Plus sign “+” indicates two or more positions/aa needed to define the epitope; amino acids not exposed at the surface of the HLA molecule are between parentheses.