Local and Systemic CD4⁺ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis

Figure 7

Longitudinal data of sarcoidosis immune function during active disease versus resolution. CD4⁺ T cells from sarcoidosis subjects that had resolved their disease while participating in our study were analyzed for parameters associated with T cell exhaustion during active disease and during disease resolution. Statistical analysis was performed using the Wilcoxon matched-pairs signed-rank test. . (a) TCR-stimulated IL-2 secretion in pg/mL. (b) TCR-stimulated IFN-γ secretion in pg/mL. (c) Percent proliferated CD4⁺ T cells. (d) Percent PD-1⁺CD4⁺ T cells.

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