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Journal of Immunology Research
Volume 2017 (2017), Article ID 3743048, 12 pages
https://doi.org/10.1155/2017/3743048
Review Article

Pathological Roles of Neutrophil-Mediated Inflammation in Asthma and Its Potential for Therapy as a Target

Department of Respiratory Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Correspondence should be addressed to Songmin Ying; nc.ude.ujz@sgniy and Yuanrong Dai; moc.621@ryiad

Received 26 May 2017; Revised 10 September 2017; Accepted 27 September 2017; Published 22 November 2017

Academic Editor: Hiroshi Nakajima

Copyright © 2017 Han Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Asthma is a chronic inflammatory disease that undermines the airways. It is caused by dysfunction of various types of cells, as well as cellular components, and is characterized by recruitment of inflammatory cells, bronchial hyperreactivity, mucus production, and airway remodelling and narrowing. It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis. Some patients display a neutrophil-dominant presentation and are characterized with low (or even absent) Th2 cytokines. In recent years, increasing evidence has also suggested that neutrophils play a key role in the development of certain subtypes of asthma. This review discusses neutrophils in asthma and potentially related targeted therapies.