Natural Killer Cells in the Orchestration of Chronic Inflammatory Diseases

Figure 2

Soluble factors within the tumour microenvironment shaping NK cell functions. Several molecules and soluble factors within the tumour microenvironment, including TGF-β, hypoxia, adenosine, acidic of the environment, and tumour exosomes (TEXOs), can inhibit NK response against tumours either by interfering with NK cell direct/cytokine mediated tumour cell lysis or by supporting tumour angiogenesis.