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Journal of Immunology Research
Volume 2017, Article ID 4768408, 9 pages
Research Article

Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren’s Syndrome

Yuzhou Gan,1,2,3 Xiaozhen Zhao,1,2,3 Jing He,1,2,3 Xu Liu,1,2,3 Yun Li,1,2,3 Xiaolin Sun,1,2,3 and Zhanguo Li1,2,3

1Department of Rheumatology and Immunology, Peking University People’s Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China
2Center of Clinical Immunology, Peking University, Beijing 100044, China
3Peking-Tsinghua Center for Life Sciences, Beijing, China

Correspondence should be addressed to Xiaolin Sun; moc.621@lxs_niloaixnus and Zhanguo Li; nc.ude.umjb@99il

Received 15 August 2016; Revised 4 November 2016; Accepted 9 November 2016; Published 22 January 2017

Academic Editor: Jacek Tabarkiewicz

Copyright © 2017 Yuzhou Gan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Th17 related immune response is pathogenic in primary Sjögren’s syndrome (pSS). However, the role of IL-17F, one potent inflammatory member of IL-17 family cytokines in pSS, has not been specifically defined. We recruited one hundred and nine pSS patients and forty-two healthy controls and their serum levels of IL-17A and IL-17F were determined by multiplex cytokine assays. White blood cell, red blood cell, neutrophil, lymphocyte, IgM, IgG, C3, C4, RF, ANA, anti-SSA antibody, and anti-SSB antibody were measured by standard laboratory techniques. EULAR Sjögren’s syndrome disease activity index (ESSDAI) score was also evaluated accordingly. We found that IL-17F was significantly increased in pSS patients. Elevated levels of IL-17F were associated with increased IgG and IgM, higher titers of ANA and anti-SSA antibodies, and reduction of C3 and C4. Patients with higher disease activity also showed higher serum IL-17F levels. However, serum IL-17A was only increased in patients with longer disease duration and showed few correlation with clinical and laboratory features in pSS patients. In conclusion, IL-17F was correlated with increased autoantibody levels and disease activity in pSS and is more clinically relevant than IL-17A.