Journal of Immunology Research / 2017 / Article / Tab 1

Review Article

Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma

Table 1

Metabolic changes associated with dendritic cell maturation and effector functions.

ReferencesCell typesActivation signalsMolecular effectMetabolic shiftsImmune response

Bajwa et al. [101]Plasmacytoid DCs (pDCs)Influenza (flu) and respiratory virusHIF1α translocation (↑)Glycolysis (↑)Interferon alpha (IFN-α) production and antiviral activity
Wu et al. [102]Plasmacytoid DCs (pDCs)TLR-9 agonist (CpG)PPAR-α-dependent FAO activity (↑)OXPHOS (↑)Interferon alpha (IFN-α) production and antiviral activity
Pantel et al. [103]CD11C+MHC II+DX5B220 splenic DCsTLR-3 agonist (poly I:C)HIF1α expression (↑)Glycolysis (↑)Interferon α/β receptor- (IFNAR-) mediated DC maturation
Malinarich et al. [104]Monocyte-derived DCs (moDCs)TLR-4 agonist (LPS)FAO activity (↑)
ATP (↓)
OXPHOS (↑)
Glycolytic capacity (↑)
Induce tolerance, negatively regulates immunogenicity
Everts et al. [54]GM-DCsTLR-4 agonist (LPS)HK-II activationGlycolysis (↑) (early events: within minutes of stimulation)Activation and function of DC
Everts et al. [75]
Amiel et al. [105]
Monocyte-derived DCs (moDCs)TLR-4 agonist (LPS)iNOS (↑)
mTOR-dependent NO (↓) production
OXPHOS (↓)
Glycolysis (↑)
(late events: after 24 hours of stimulation)
DC survival and inflammation
Boukhaled et al. [106]DCs constitutively expressing transcriptional repressor: PCGF6TLR agonist (LPS)Active transcriptional silencing by histone demethylationGlycolysis (↓)Maintenance of DC quiescence
Wang et al. [30]Tsc1-deficient bone marrow-derived DCsSpontaneousmTORC-1 activity (↓)Glycolysis (↑)
OXPHOS (↑)
Checkpoint of DC development and differentiation; DC-mediated T cell response

Note that this list is not exhaustive. DC: dendritic cell; HIF1α: hypoxia-inducible factor 1α; PPAR-α: peroxisome proliferator-activated receptor-α; FAO: fatty acid oxidase; TLR: toll-like receptor; HK-II: hexokinase II; PCGF6: polycomb group factor 6; Tsc1: tuberous sclerosis 1; ROS: reactive oxygen species; iNOS: inducible nitric oxide synthase; ATP: adenosine triphosphate; mTORC 1: mammalian target of rapamycin complex I.