Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma

Figure 3

Local administration of suramin inhibits neutrophilic airway inflammation and remodeling. (a) Suramin inhibited the infiltration of neutrophils and macrophages into BALF. BALF was collected at 24 h after the last OVA challenge. Differential cells were counted in the BALF of mice in control, asthma, vehicle-treated, and suramin-treated groups. The values represent the means ± SEM (). and compared with the asthma group. (b) Representative H&E and Masson staining of lung tissues. H&E-stained lung tissues (upper panel) from mice in control—A, asthma—B, vehicle-treated—C, and suramin-treated groups—D. Masson-stained lung tissues (lower panel) from mice in control—E, asthma—F, vehicle-treated—G, and suramin-treated groups—H. (c) Inflammation scores were decreased in suramin-treated mice. The values represent the means ± SEM (). and compared with the asthma group. (d) The proportion of collagen area was decreased in suramin-treated mice. The values represent the means ± SEM (). and compared with the asthma group.

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