Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma

Figure 8

Suramin impedes the potential of ATP-induced Th17 responses in vivo. DO11.10 mice were challenged with an aerosolized solution of PBS or OVA from days 0 to 2, and suramin was intratracheally administered at 30 min before each OVA challenge. All mice were sacrificed for analysis on day 3. (a) Total and differential cells counts and (b) cytokine profiles were analyzed in the BALF. Values represent the means ± SEM (). and compared with the OVA group.

(a)

(b)